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Injectable Solution Preparation System 300-500L with SS316L Tank (Sterile Grade, Loop Circulation Design)

Categories Solution Preparation Systems
Material: SS316L (Product Contact Parts), SS304 (Frame)
Function: Mixing, Heating & Cooling Jacket, CIP/SIP Cleaning System
Packaging Details: Export Standard Wooden Box
Certification: ISO,CE
Delivery Time: 15 Days
Control System: PLC Automatic Control with Touch Screen (Siemens/Schneider Optional)
Brand Name: CHONGYANG
Model Number: CY-SPS-500L
Application: Pharma / Biopharma / Cosmetic / Food Industry
Place of Origin: CHINA
Payment Terms: T/T, L/C
Surface Finish: Internal Ra ≤0.4μm, External Matte/Polished
Capacity: 300L / 500L / 1000L / 2000L / 3000L / Custom
Supply Ability: 100 sets/Month
MOQ: 1
Price: Negotiation
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Injectable Solution Preparation System 300-500L with SS316L Tank (Sterile Grade, Loop Circulation Design)

Injectable Solution Preparation System 300–500L with SS316L Tank

Introduction

The 300–500L Injectable Solution Preparation System is designed for high-purity liquid preparation under controlled hygienic and sterile-grade processing conditions.

Featuring an SS316L product-contact tank, sanitary loop circulation, precision agitation, optional heating and cooling, sterile filtration, and PLC/HMI automation, the system provides uniform mixing, stable temperature control, reliable batch repeatability, and reduced contamination risk.

The system can be customized for injectable solution preparation, biotechnology media, sterile buffers, high-purity formulations, laboratory production, and other clean-process applications.

Product Overview

The 300–500L Injectable Solution Preparation System is an integrated sanitary process skid for mixing, circulation, temperature control, filtration, storage, and sterile transfer.

Product-contact surfaces are manufactured from SS316L stainless steel, while external structures can be fabricated from SS304.

The loop circulation design continuously returns the solution through the tank and external circulation pipeline, helping maintain uniform concentration, temperature, and product quality throughout the batch.

The closed sanitary system minimizes manual exposure and supports reliable operation in cleanrooms, sterile preparation areas, pharmaceutical facilities, biotechnology plants, and high-purity production environments.

Application Industries

Sterile Liquid Preparation
Injectable Solution Formulation
Biotechnology Media Preparation
Buffer Preparation
High-Purity Liquid Formulation
Sterile Cosmetic Processing
Laboratory Production
Cleanroom Manufacturing

Production Process

The following process flow shows a typical sterile-grade injectable solution preparation sequence.

Purified Water Source
Raw Material Dosing
300–500L Mixing Tank
Agitation
Loop Circulation
Heating / Cooling
Sterile Filtration
Sterile Transfer
Storage Tank

Purified water and raw materials are introduced into the preparation vessel. The agitator provides primary blending, while the external circulation loop maintains continuous solution movement and uniformity. The heating or cooling jacket controls process temperature before the solution passes through sterile filtration and sanitary transfer.

Features and Advantages

SS316L Product-Contact Parts

Hygienic construction with excellent corrosion resistance.

Loop Circulation Design

Supports continuous mixing and uniform solution quality.

Smooth Internal Surface

Ra ≤ 0.8 μm standard, with Ra ≤ 0.6 or 0.4 μm options.

Closed-System Processing

Minimizes contamination risk and operator exposure.

Heating and Cooling Jacket

Provides accurate batch temperature control.

PLC / HMI Automation

Enables automatic operation, alarms, and process monitoring.

CIP / SIP Ready

Supports cleaning and sterilization of the preparation system.

Skid-Mounted Construction

Simplifies installation, connection, and commissioning.

Technical Specifications

ItemSpecification
Nominal Capacity300–500 L
Product-Contact MaterialSS316L
External MaterialSS304
Internal Surface FinishRa ≤ 0.8 μm; Ra ≤ 0.6 or 0.4 μm optional
Mixing MethodTop agitator with sanitary loop circulation
Mixing Speed0–60 rpm, adjustable
Circulation FlowAdjustable according to process requirement
Heating / CoolingSanitary jacket, optional
Control SystemPLC with touchscreen HMI
Cleaning and SterilizationCIP / SIP ready
Working Pressure0–0.3 MPa, subject to final vessel design
Design Temperature-10°C to 120°C
Power Supply220V / 380V, 50 or 60 Hz, customizable
InstallationSkid-mounted
Design BasisGMP-oriented hygienic engineering and ISO quality management

Final specifications depend on product characteristics, process temperature, operating pressure, viscosity, mixing time, cleaning strategy, and customer URS.

Standard Configuration

ComponentDescription
Mixing Tank300–500L SS316L vessel with sanitary manway and process nozzles
AgitatorTop-mounted sanitary agitator with variable-speed drive
Circulation PumpSanitary pump for continuous loop circulation
Jacket SystemOptional heating and cooling jacket
Control PanelPLC, touchscreen HMI, alarms, and process interlocks
ValvesSanitary diaphragm valves, manual or automatic
PipingSS316L hygienic piping with drainable arrangement
Filtration UnitSanitary sterile-filtration housing according to process requirement
CIP / SIP InterfaceCleaning and sterilization connections
InstrumentationTemperature, pressure, level, speed, and optional flow instruments
Skid FrameIntegrated stainless-steel support frame

Why Use a Loop Circulation Design?

The circulation loop continuously withdraws solution from the vessel, passes it through the sanitary external circuit, and returns it to the tank.

More uniform ingredient distribution
Reduced concentration variation
Improved temperature consistency
Improved filtration integration
Better drainability and cleanability
Stable product quality throughout the batch

Optional Configurations

300L or 500L Capacity
Ra ≤ 0.4 μm Electropolished Finish
Automatic Diaphragm Valves
Load-Cell Weighing System
Automatic Raw-Material Dosing
Sterile Vent Filter
Nitrogen Blanketing
Online Conductivity Monitoring
Recipe Management
Audit Trail and 21 CFR Part 11 Option
Integrated CIP Station
Automatic SIP Sequence

Typical Project Applications

Southeast Asia Cleanroom Facility

A 500L system with loop circulation improved mixing uniformity and reduced batch variation.

Middle East High-Purity Production Line

The closed-loop design supported stable operation and reduced contamination risk during preparation and transfer.

Design Standards and Documentation

  • GMP-oriented hygienic design principles
  • ISO 9001 quality-management manufacturing
  • SS316L product-contact materials
  • Sanitary fittings and drainable piping
  • Material certificates and surface-finish records
  • Optional FAT, DQ, IQ, and OQ documentation
  • Optional FDA- and WHO-oriented project documentation

Frequently Asked Questions

What is the benefit of loop circulation?

Loop circulation provides continuous solution movement, helping maintain uniform concentration, temperature, and product quality.

Is the system suitable for sterile applications?

The system can be engineered for sterile-grade preparation with SS316L contact parts, closed processing, sterile filtration, CIP, and optional SIP.

Can the capacity and configuration be customized?

Yes. Tank capacity, piping, instruments, mixing speed, circulation flow, filtration, control logic, and documentation can be customized.

Is automatic operation available?

Yes. PLC and touchscreen HMI control can be provided for automatic operation, alarms, recipes, temperature control, and batch monitoring.

Does the system support cleaning and sterilization?

Yes. The skid can include CIP connections, spray devices, drainable piping, and optional SIP sterilization sequences.

Why Choose CHONGYANG WATER?

CHONGYANG WATER provides customized injectable solution preparation systems, liquid preparation skids, sterile tanks, loop-circulation systems, CIP/SIP solutions, and pharmaceutical clean-utility integration.

Customized Process Engineering
SS316L Hygienic Fabrication
Sanitary Loop Circulation
PLC / HMI Automation
CIP / SIP Integration
FAT and Documentation Support
2D and 3D Layout Design
Installation and Commissioning Guidance

Need a Sterile-Grade Injectable Solution Preparation System?

Share your required batch capacity, product characteristics, mixing time, process temperature, circulation requirement, filtration grade, CIP/SIP strategy, and automation level with our engineering team.

CHONGYANG WATER can prepare a customized technical solution, equipment configuration, process flow, layout drawing, and quotation for your project.

China Injectable Solution Preparation System 300-500L with SS316L Tank (Sterile Grade, Loop Circulation Design) factory
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