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White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

Categories Local Anaesthesia Drugs
Brand Name: LSW
Model Number: 62-44-2
Certification: ISO9001,BRC,KOSHER
Place of Origin: CN
MOQ: 10g
Price: Negotiation
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5-8 working days
Delivery Time: 5-8 working days
Packaging Details: Discreet package
Product Name: Phenacetin
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Appearance: white crystalline powder
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    White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

    CAS:62-44-2 White Flash Scaly Crystalline Powder Pharmaceutical Grade Phenacetin Anti Inflammatory Pain Relieving Drugs
    Basic information
    Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations
    Product Name: Phenacetin
    Synonyms: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
    CAS: 62-44-2
    MF: C10H13NO2
    MW: 179.22
    EINECS: 200-533-0
    Product Categories: Other APIs;Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
    Mol File: 62-44-2.mol
    Phenacetin Structure
    Phenacetin Chemical Properties
    Melting point 133-136 °C(lit.)
    Boiling point 132 °C / 4mmHg
    Fp 2℃
    storage temp. 2-8°C
    form powder
    color White
    Water Solubility 0.076 g/100 mL
    Sensitive Hygroscopic
    Merck 14,7204
    BRN 1869238
    Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
    Uses:
    Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C.," or "aspirin-phenacetin-caffeine" compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia.
    But the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November of 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
    Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.
    Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
    Product Description:
    Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA on its use in the United States. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.
    It is also called acetophenetidins. Having glossy leaflets or scales-like crystals that have no odor or taste.Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever,headache, neuralgia and other drugs as a compound agent.
    COA:
    ItemSpecificationsResults
    DescriptionWhite or almost white crystalline powderConform
    Identity1,IR compliesConform
    2,X-Ray compliesConform
    3,HPLC compliesConform
    Optical rotation-77.0-78.0
    Loss on dryingNot more than 0.5%0.32%
    Related substances1,Cabergolin Imp A no more than0.15%0.05%
    2,Allylamide no more than 0.10%0.03%
    3,Allyl DHLA no more than 0.15%0.06%
    4,Cabergoline oxide no more than 0.10%0.04%
    5,Other impurities individually no more than 0.10%0.03%
    6,Total no more than 0.50%0.21%
    Assay(HPLC)98.0%~102.0%(recalculated on anhydrous basis)99.4%
    Residual solvents1,Dichloromethane no more than 100ppm15ppm
    2,Acetone no more than 200ppm15ppm
    3,Tert-butylmethylether no more than 200ppm11ppm
    4,Xylene no more than 1500ppm135ppm
    5,Heptane no more than 1000ppm20ppm
    Residue on ignitionNo more than0.10%0.03%
    Heavy metalsNo more than 20ppm1ppm
    Particle size90% of particles no more than 80umConform
    Bulk density0.20~0.35g/cm30.33g/cm3
    ConclusionThe results conforms with EP6.0/USP30 standard.
    Mechanism of action:
    Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
    It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.
    Phenacetin Function
    Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic effect. Because the enzyme inhibitor make Phenacet-Acetate not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The mild Phenacet-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.

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