99% Purity Powder Phenacetin pharmaceutical raw materials 62-44-2
Product Name: Phenacetin
Garde: Pharmaceutical grade
Appearance: white powder
Packing: aluminum foil bag
Ingredients: acetoethoxy aniline
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
storage temp. 2-8°C
Water Solubility 0.076 g/100 mL
Stability: Stable. Incompatible with strong oxidizing agents,
1. Used for organic synthesis of raw materials and drug
intermediates from acetaminophen ether.
2. Antipyretic analgesics for the treatment of fever, headache,
3. Active pharmaceutical ingredient for Scientific Research.
The antipyretic and analgesic effects of phenacetin are similar to
that of acetylsalicylic acid, which is mainly used as
anti-inflammatory drugs with a slow and long-lasting effect. It is
an effective drug on the treatment of headache, neuralgia, joint
pain and fever. However, it has a weak effect on treating
anti-rheumatic, anti-inflammatory. Overdose can cause
methemoglobinemia, resulting in hypoxia. Long-term medication can
damage the kidneys, and even cause papillary necrosis, thus it
should be taken with caution. Owing to its side effect and the
rapid development of other similar drugs, the drug has been
discontinued alone and just used as an active pharmaceutical
ingredient for compound preparation with other drugs. It is often
combined with aspirin, caffeine, for making aspirin compound (0.162
g of non-phenacetin, 0.227 g of aspirin, and 0.035 g of caffeine)
for the treatment of colds with a small toxicity. Further addition
of a small amount of the chlorpheniramine can produce
chlorpheniramine cold tablets which can be applied to the treatment
of colds, headache, neuralgia, rheumatism and so on.
Methods of Production
(1) By acetylation reaction from a p-aminophenyl ether. Heat the
mixture of benzene, acetic anhydride and amino benzene ether on an
oil bath azeotropically for 4h. Then cool the reaction mixture
after completion of the reaction, getting precipitate of statins.
Filter, washed with cold benzene and then dry to get the final
product. The yield usually can reach 86% of the theoretical amount.
(2) By the reaction of sodium ethoxide and acetamidophenol: first
add acetamidophenol into sodium ethoxide, and then slowly add ethyl
iodide to heat and reflux for 1h, cool, filter, and the dissolve
the crude product in ethanol. Filter and dilute the filtrate with
water, and then cool, filter, and dried to obtain the final
product. The yield can be 80% of the theoretical amount. At the
first method, we can also use acetate instead of benzene as the
solvent with the following process: heat 40% diluted acetic acid to
boiling, add phenetidine and distill off the water. Add acetate
when the temperature rise to 150 °C, reflux for 1h and continue to
steam until the temperature rises above 150 °C, do sampling for
determination of free amino benzene ether. Add certain amount of
acetic anhydride based on the amount of residual phenetidine acetic
anhydride, and the subject to reflux reaction for another 0.5h.
Check the end, and reduce pressure if the product is qualified.
Recycle acetate until the product contains 0.046 or less amino
content and 0.2% or less acid. Press the reaction mixture back into
the hot refined mother liquor, cool the mixture to 40 °C through
stirring, filtrate and get the phenacetin crude product. For
refining, add boiling water or refined mother liquor to phenacetin
crude product, dissolve it through heated stirring, filter, and
adjust the filtrate to pH = 4.5-4.7 with acid. Add activated carbon
and sodium thiosulfates to stir for bleaching, filter and cool and
crystal the filtrate liquid cooling crystallization, apply it to
rejection filter, air dried to obtain phenacetin final product.
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